The ENTIRE collection of resources provided by the BBC Library can now be searched on ONE single, powerful search platform, which retrieves print books, eBooks, database articles and websites. Click HERE for assistance.
The following websites and articles will not provide all the answers you require to complete your assignment. However, they will provide you with an excellent start to your research needs. All sites and documents were found using the Research Hints listed on this Research Guide.
CRISPR
CRISPR - key reads : Nature International Weekly Journal of Science
CRISPR - gene editing is just the beginning : Nature International Weekly Journal of Science
Questions and answers about CRISPR : The Broad Institute
The promise of Gene editing : BBC news
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Induced Pluripotent Stem Cells (iPS cells)
The promise of Induced Pluripotent stem cells : National Institute of Health, USA
Progress towards the clinical application of patient-specific pluripotent stem cells : JCI The Journal of Clincial Investigation
Induced pluripotent stem cells — opportunities for disease modelling and drug discovery : Nature Reviews
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RNA therapeutics
RNA Therapeutics Institute - University of Massachusetts Medical School
Try using a University site or a well-known Education/Government site which specialises in your topic and provides links to free web sources.
Search within the website – Genome editing / CRISPR etc.
National Library of Medicine – US
National Institute of Health - US
PubMED - US
Cochrane Library (Clinical Trials)
Full text available for those articles with DOI link (digital object identifier).
Some research tips to get you started
Hints:
Referencing:
For all the information you require when referencing at BBC - go to the Referencing Help page created by Ms King.
Creating iPS cells : Eli and Edythe Broad Stem Cell Research Center at UCLA
Genome editing with CRISPR - Cas9 : McGovern Institute for Brain Research at MIT
CRISPR - The new tool in the gene revolution explained : ABC Science
CRISPR - A word processor for editing the genome : iBiology
Jennifer Doudna explains the birth of breakthrough technology CRISPR Cas9 : iBiology
RNA Interference : Nature Research
We recommend the following databases for this assignment.
When you are away from the campus you will need to login using the appropriate username and password - previously sent to you by email from Ms King
CRISPR
CRISPR Cas9 gene editing (2017) - Access Science
DNA Revolution (2016) – Science Reference Centre
Excellent diagrams and the article discusses the emergence of the revolutionary technology CRISPR-Cas9 and gene drive combination which can be used in altering, deleting and rearranging the DNA of living organisms
The original CRISPR (2017) – ANZRC
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Induced Pluripotent Stem Cells (iPS cells)
Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications (2018) - Gale: Expanded Academic ASAP
The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was heralded as a major breakthrough of the decade in stem cell research. The ability to reprogram human somatic cells to a pluripotent embryonic stem cell-like state through the ectopic expression of a combination of embryonic transcription factors was greeted with great excitement by scientists and bioethicists. The reprogramming technology offers the opportunity to generate patient-specific stem cells for modeling human diseases, drug development and screening, and individualized regenerative cell therapy
Induced pluripotent stem cells – Access Science
Introduction to technology with diagram.
All Eyes on Stem Cells – ANZRC
Biologist Masayo Takahashi at the Riken Center for Developmental Biology in Kobe, Japan discusses why the first ever human study using induced pluripotent stem (iPS) cells is such a big deal, how would treatment with iPS cells work, and dangers associated with iPS cell treatments
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RNA therapeutics
Overcoming cellular barriers for RNA therapeutics (2017) - Gale: Expanded Academic ASAP
RNA-based therapeutics, such as small-interfering (siRNAs), microRNAs (miRNAs), antisense oligonucleotides (ASOs), aptamers, synthetic mRNAs and CRISPR–Cas9, have great potential to target a large part of the currently undruggable genes and gene products and to generate entirely new therapeutic paradigms in disease, ranging from cancer to pandemic influenza to Alzheimer’s disease.
RNA Therapeutics in Cardiovascular Precision Medicine (2018) - Gale: Expanded Academic ASAP
Since our knowledge on structure and function of messenger RNA (mRNA) has expanded from merely being an intermediate molecule between DNA and proteins to the notion that RNA is a dynamic gene regulator that can be modified and edited, RNA has become a focus of interest into developing novel therapeutic schemes.